Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

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Chronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia.Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems.This is of particular significance in Sub-Saharan Africa where helminthic infections are a Neff I96BMV5N5B 90cm Stainless Steel Island Cooker Hood more prevalent cause of eosinophilia.To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian.He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly.

Good symptomatic control was achieved using Graduation Teddy Bear Gift Box hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor.Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.